1. What is Semax?

Semax is a synthetic heptapeptide derived from the ACTH(4–10) fragment and studied for neurobiological properties in laboratory and academic settings. Research literature describes investigation into cognition-related pathways, neuronal stress responses, and cerebrovascular biology. All references herein relate to in-vitro and preclinical/observational research contexts.

2. Semax Structure

Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro

Molecular Formula:C₃₇H₅₁N₉O₁₀S

Molecular Weight: 813.9 g/mol

PubChem ClD:122178

CAS Number: 80714-61-0

Synonyms: Pro-Gly-Pro-ACTH

3. Semax Research

Semax (ACTH(4–10) analogue with a Pro-Gly-Pro extension) has been examined as a neurobiologically active peptide with notable stability in experimental systems.

Molecular pathways (research): Studies report modulation of neurotrophin-related signaling (e.g., BDNF/TrkB) and monoaminergic tone, alongside antioxidant and inflammatory gene programs in models of neuronal stress. See overviews and primary reports:

Mechanistic/overview: 【1】

General reference: 【2】

Cell/animal models: Publications describe effects on oxidative stress markers, transcriptional responses after cerebral ischemia, and learning/memory readouts in rodent tasks (water-maze, passive-avoidance).

Example review: 【3】

Related neurochemistry report: 【4】

Human research reports: Small research cohorts have explored attention and working-memory endpoints with neuroimaging correlates; these are exploratory and not determinative for clinical use.

Summary dossier: 【5】

This section is informational about published research and does not imply use, suitability, or safety in humans or animals.

✅ Why Consider Semax?

·  Neurobiological signaling: Investigated for interactions with neurotrophin and monoamine pathways in experimental systems.

·  Stress/oxidative programs: Reported modulation of redox and inflammatory gene networks in vitro and in animal models.

·  Transcriptional profiling: Transcriptomic studies suggest broad gene-program engagement following neural stress in model organisms.

4. Future Semax Research

·  Larger controlled studies: To clarify reproducibility, effect sizes, and safety profiles across diverse experimental conditions.

·  Mechanistic mapping: High-resolution ‘omics to delineate targets across synaptic plasticity, vascular biology, and neuroimmune signaling.

·  Formulation science: Stability, peptide analytics, and delivery to model systems (e.g., tissue/cell platforms) for consistent laboratory results.

5. Application Areas

Neuroscience research: Synaptic plasticity, learning/memory models, stress-response pathways.

Vascular & ischemia models: Gene-expression and redox studies following experimental ischemic paradigms.

Translational discovery: Preclinical screening of neuroprotective hypotheses in cell and animal systems.

✅ Summary

Semax is an ACTH-derived research peptide examined for effects on neurotrophin signaling, monoamines, oxidative stress, and transcriptional responses in preclinical and exploratory research settings. The information above is provided for scientific background only and does not describe or suggest any use in humans or animals.

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The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.