1. What is Semaglutide?
Semaglutide is a synthetic glucagon-like peptide-1 receptor agonist (GLP-1RA) originally developed for research into type 2 diabetes and obesity. It mimics the activity of endogenous GLP-1, a hormone that regulates glucose metabolism and appetite. By engaging GLP-1 receptors, Semaglutide enhances insulin secretion, reduces glucagon output, slows gastric emptying, and increases satiety, supporting improvements in metabolic balance and body weight regulation.
2. Semaglutide Structure
Sequence:HXEGTFTSDVSSYLEGQAAK-OH.steric diacid-EFIAWLVRGRG
Molecular Formula:C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 g/mol
PubChem ClD: 56843331
CAS Number: 910463-68-2
3. Semaglutide Research
Molecular Properties & Mechanisms
l Insulin secretion: Enhances cAMP/PKA signaling in pancreatic β-cells.
l Glucagon regulation: Reduces α-cell glucagon release, decreasing hepatic glucose output.
l Satiety & appetite: Engages hypothalamic GLP-1R to modulate hunger signals .
l Gastric emptying: Slows digestion, improving post-meal glycemic control 【1】.
l Lipid metabolism: Encourages adipose “browning,” reduces visceral fat, and enhances oxidation 【2】.
Pharmacokinetics
l Injectable form: Long half-life (~7 days) due to albumin binding.
l Oral form: Absorption aided by SNAC carrier; Tmax ~1 h when taken fasting 【3】.
4. Clinical Efficacy & Outcomes
· Weight Reduction (STEP & SELECT):
– 68-week study: 12–15% (~15 kg) mean weight loss 【4】.
– 4-year SELECT: sustained ~10% loss, 20% reduction in CV events 【5】.
· Glycemic Benefits:
– SUSTAIN-6 trial: 26% reduction in cardiovascular risk in high-risk T2D patients 【6】.
· Body Composition:
– Preferential fat mass reduction with lean mass preservation 【7】.
– Waist reduction ~7.7 cm; improved waist-to-height ratio.
· Cardiovascular & Cognitive:
– Improved BP, lipids, and inflammation markers.
– Observational data: ~37% dementia risk reduction, ~19% stroke reduction .
5. Tolerability & Patient Confidence
✅ Generally well-tolerated with established titration protocols.
✅ Flexible dosing: once-weekly injectable or once-daily oral.
✅ Non-stimulant, non-habit-forming.
✅ Preferred by users vs. other GLP-1 therapies in comparative studies.
Lifestyle guidance (hydration, protein-rich meals, exercise) enhances outcomes and satisfaction, while supporting energy, confidence, and adherence.
6. Usage Highlights & Lifestyle Integration
📆 Flexible Formats: Weekly subcutaneous or daily oral.
🧃 Nutrition Synergy: Works alongside balanced, protein-focused diets.
🏋️ Activity Support: Preserves lean mass and complements physical training.
👩⚕️ Clinician-endorsed: Supported by large-scale trials and real-world global adoption.
✅ Summary
Semaglutide is a long-acting GLP-1RA delivering clinically validated benefits across weight management, glycemic control, cardiovascular protection, and body composition improvement. With both injectable and oral availability, it offers broad flexibility and sustained results. Ongoing studies also suggest neuroprotective and hormonal support roles, further highlighting its versatility in metabolic research.
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The products offered on this website are furnished for in-vitro studies only (Latin: in glass). These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
