1. What is Selank?

Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide Tuftsin. It has been extensively studied in neuroscience research for its potential roles in anxiolytic (anti-anxiety), cognitive, and neuroprotective mechanisms. Selank is often investigated as a nootropic peptide, showing activity in modulating neurotransmitters, improving stress resilience, and supporting memory function.

2. Selank Structure

Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

Molecular Formula: C₃₃H₅₇N₁₁O₉

Molecular Weight: 751.9 g/mol

CAS Number: 129954-34-3

PubChem CID: 3081378

Synonyms: TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Tuftsin analog

3. Selank Research

【1】 Molecular & Cellular Mechanism

•  Tuftsin analog activity: Retains immunomodulatory functions of tuftsin while extending into neuropeptide research【1】.
•  Neurotransmitter regulation: Shown to increase levels of serotonin, dopamine, and norepinephrine in preclinical studies【2】.
•  GABAergic modulation: Enhances inhibitory neurotransmission, linked to its anti-anxiety profile.
•  BDNF upregulation: Stimulates brain-derived neurotrophic factor, supporting neuroplasticity and resilience.
•  Epigenetic effects: Suggested to regulate gene expression related to mood, learning, and immune balance.

【2】 Preclinical & Translational Data

•  Anxiolytic effects: Demonstrated in animal models with stress-reducing behavior similar to mild tranquilizers, but without sedation【3】.
•  Cognitive improvement: Enhances learning and memory in rodent maze tasks and stress-challenged models.
•  Immune modulation: Influences cytokine production and supports immune system balance.
•  Neuroprotection: Shown to protect neurons under oxidative and ischemic conditions.
•  Comparative studies: Often studied alongside Semax, highlighting complementary but distinct neuroactive properties.

✅ Why Consider Selank?

🧠 Nootropic value: Studied for supporting memory, focus, and learning.
😌 Stress resilience: Reduces anxiety-like behavior in preclinical models.
⚖️ Neurotransmitter balance: Modulates serotonin, dopamine, and GABA activity.
🌿 Immune regulation: Retains immunomodulatory effects from tuftsin origin.
🔬 Neuroprotective potential: Investigated for oxidative and ischemic stress protection.
🔄 Synergy with Semax: Complements Semax in cognition and stress-related research.

4. Future Selank Research

Expanded mood & anxiety studies: Further translational trials in stress, depression, and anxiety models.

Cognition & neurodegeneration: Potential exploration in Alzheimer’s, age-related decline, and memory disorders.

Immune-neuro axis studies: Mapping its dual action in both immune and CNS regulation.

Epigenetic profiling: Detailed mapping of Selank-driven gene expression changes.

Combination regimens: Research into synergistic use with Semax, DSIP, or BDNF-linked peptides.

5. Application Areas

✅ Summary

Selank is a short synthetic peptide with roots in immune regulation and broad application in neuroscience research. It has been widely studied for its anxiolytic, nootropic, and neuroprotective effects, making it a valuable research tool for stress biology, cognition, and immune-neuro interactions. Its complementary profile to Semax highlights its role as a unique and versatile peptide in neuroactive studies.

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The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.