1. What is PE-22-28?
PE-22-28 is a synthetic peptide fragment derived from the naturally occurring neuropeptide galanin. It consists of seven amino acids (a short C-terminal sequence of galanin) and has been studied for its neurological, mood, and stress-related regulatory properties. In experimental research, PE-22-28 is investigated for its potential influence on neuroprotection, emotional regulation, and receptor selectivity.
2. PE-22-28 Structure
Sequence: GWTLNSL
Molecular Formula: C₃₅H₅₅N₁₁O₉
Molecular Weight: 773.89 g/mol
CAS Number: 1801959-12-5
PubChem CID: 3081377
Synonyms: Galanin Fragment (22-28), Galanin (22-28) amide
3. PE-22-28 Research
【1】 Molecular & Cellular Mechanisms
- Galanin receptor binding: Selectively interacts with galanin receptors (GALR2/3), showing greater neuromodulatory and antidepressant-like activity compared to the full-length galanin peptide 【1】.
- Stress resilience: Reported to reduce behavioral stress responses in preclinical animal studies.
- Neuroprotection: Demonstrated protective effects in neuronal models under oxidative and excitotoxic stress.
- Mood regulation: Enhances serotonergic and dopaminergic signaling pathways in experimental settings.
【2】 Preclinical Evidence
- Antidepressant-like effects: Animal models suggest significant mood-enhancing effects without sedation 【2】.
- Neurocognitive research: Supports memory consolidation and learning behaviors in stress-challenged models.
- Neuroprotective role: Shown to improve neuron survival and reduce degeneration in cellular assays.
- Selectivity advantage: Unlike full galanin, PE-22-28 shows fewer inhibitory side effects, making it useful for mechanistic research into mood and cognition.
✅ Why Consider PE-22-28?
🧠 Neuro-selective fragment: Targets galanin pathways linked to mood and cognition.
⚖️ Balanced modulation: Provides neuroregulatory effects without strong inhibitory actions of full galanin.
🔬 Research value in stress biology: Studied in resilience, mood, and neuroprotection models.
📊 Preclinical promise: Evidence suggests benefits for learning, memory, and emotional balance.
🌍 Compact & stable: A short heptapeptide, easy to synthesize and store for lab use.
4. Future PE-22-28 Research
Mood & behavior studies: Expanded animal and translational trials to confirm antidepressant-like activity.
Neurodegeneration models: Potential applications in Parkinson’s, Alzheimer’s, and oxidative stress studies.
Cognitive enhancement: Investigations into learning, memory, and executive function.
Biomarker profiling: Identifying molecular pathways and receptor subtypes responsible for activity.
Formulation improvements: Development of stabilized, targeted delivery systems for consistent lab outcomes.
5. Application Areas
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Scenario
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PE-22-28 Contribution
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Mood & stress biology
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Studied for resilience, stress response, and emotional regulation
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Neuroprotection
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Supports neuron survival in oxidative/excitotoxic models
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Cognitive research
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Linked to improved memory and learning
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Galanin pathway exploration
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Acts as a selective galanin receptor fragment
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Neurodegeneration models
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Investigated in preclinical studies for protective effects
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✅ Summary
PE-22-28 is a compact galanin-derived peptide fragment with unique receptor selectivity and neuro-active potential. Its experimental profile makes it valuable for studies on mood regulation, stress resilience, neuroprotection, and cognitive function. With a strong foundation in preclinical research, PE-22-28 continues to serve as a specialized tool in neuroscience and peptide biology.
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The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
