1. What is Palmitoyl Pentapeptide?
Palmitoyl Pentapeptide (commonly referred to as Palmitoyl Pentapeptide-4 or Matrixyl®) is a synthetic lipid-conjugated peptide widely studied in cosmetic and dermatological research. It consists of a short amino acid chain (KTTKS: Lys-Thr-Thr-Lys-Ser) linked to a palmitic acid group, enhancing stability and dermal penetration. Palmitoyl Pentapeptide is recognized for its ability to act as a biomimetic signal peptide, supporting extracellular matrix (ECM) remodeling, collagen stimulation, and visible skin rejuvenation effects in research settings.
2. Palmitoyl Pentapeptide Structure
Molecular Formula： C₃₉H₇₅N₇O₁₀
Molecular Weight：802.05g/mol
CAS Number：214047-00-4
3. Palmitoyl Pentapeptide Research
【1】Mechanism of Action
l Dermal signaling: Mimics collagen fragments to activate fibroblast receptors and stimulate ECM protein synthesis (collagen I/III/IV, elastin, fibronectin, hyaluronic acid).
【1】
l ECM remodeling & protection: Promotes synthesis while reducing collagen breakdown.
l Photo-aging defense: Counters UV-induced ECM degradation by upregulating dermal repair pathways.
【2】
l Stability & penetration: Palmitoyl modification improves skin uptake and molecular stability.
【2】Clinical & Preclinical Evidence
l Controlled studies (0.005–3% creams): Reported reductions in wrinkle depth, roughness, and thickness after 12 weeks of twice-daily application.
【3】
l Higher-concentration serums (3–7%): Pilot trials suggest faster improvements in elasticity and smoothness.
l Wound-healing models in animals: Enhanced collagen deposition and tissue repair compared to controls.
l Safety: Generally well tolerated at cosmetic concentrations, with low irritation potential.
✅ Why Consider Palmitoyl Pentapeptide?
l 🧬 Signal peptide action: Mimics collagen fragments to stimulate fibroblasts.
l 💪 Supports ECM regeneration: Boosts collagen, elastin, and glycosaminoglycan synthesis.
l ✨ Visible skin improvements: Studies show reduced fine lines and improved elasticity.
l 💧 Hydration & barrier support: Enhances dermal water-binding molecules.
l 🌿 Non-invasive option: Gentle alternative for sensitive or mature skin.
l 🔄 Synergy-friendly: Pairs well with retinoids, niacinamide, antioxidants, and sunscreen.
4. Future Palmitoyl Pentapeptide Research
l Formulation optimization: Liposomal and nano-delivery systems under development to enhance dermal penetration.
l Combination therapies: Synergistic blends with tripeptides, niacinamide, and retinoids show improved collagen synthesis in vitro.
l High-dose exploration: Trials with 7% serums are underway to test dose–response efficiency.
l Adjunct protocols: Integration with microneedling, LED, and RF therapies for enhanced dermal outcomes.
l Broader skin applications: Preliminary research into scars, hyperpigmentation, and inflammatory dermatoses.
l Peptidomics mapping: Structure–activity relationship studies on related palmitoylated peptides.
5. Application Areas
l Anti-aging formulations: Commonly used in serums and creams to support wrinkle reduction.
l Eye treatments: Popular for periorbital products targeting crow’s feet.
l Dermal repair support: Post-procedure skincare (chemical peels, micro-needling, laser).
l Hydration serums: Improves comfort in dry or mature skin.
l Next-gen formulations: Potential role in microbiome-supportive and prebiotic skincare research.
✅ Summary
Palmitoyl Pentapeptide-4 (Matrixyl®) is one of the most studied cosmetic peptides, functioning as a biomimetic signal that supports collagen renewal, ECM remodeling, and improved skin resilience. Evidence highlights its ability to reduce fine lines and wrinkles, improve firmness, and enhance skin texture and hydration in controlled studies. With its excellent tolerability and compatibility with other actives, Palmitoyl Pentapeptide continues to play a central role in advanced cosmeceutical research. Future work is exploring enhanced delivery, high-dose formulations, and expanded dermatological applications.
⚠️ Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
