1. What is Oxytocin Acetate?
Oxytocin Acetate is the acetate-salt form of oxytocin, a naturally occurring nonapeptide hormone/neuropeptide synthesized in the hypothalamus and stored in the posterior pituitary. While oxytocin is historically recognized for roles in reproduction and lactation, ongoing research has expanded its relevance to social bonding, stress response, immune regulation, pain modulation, and metabolic signaling. Current studies highlight Oxytocin Acetate as a versatile research tool in neuroscience, endocrinology, and immunology.
2. Oxytocin Acetate Structure
Sequence:Cys(1)-Tyr-lle-GIn-Asn-Cys(1)-Pro-Leu-Gly
Molecular Formula: C₄₅H₇₀N₁₂O₁₄S₂
Molecular Weight: 1067.24 g/mol
CAS Number: 50-56-6
Synonyms: Pitocin,Endopituitrina, Ocytocin
3. Oxytocin Acetate Research
【1】Molecular & Receptor Signaling
l Oxytocin binds to oxytocin receptors (OTR), a GPCR, initiating cascades including PLC/IP₃/DAG, Ca²⁺ release, PKC/MAPK, PKA, and PI3K/NO pathways, influencing muscle contraction, cell signaling, inflammation, and neural communication.【1】
l Oxytocinase enzymes regulate oxytocin turnover, particularly in pregnancy.
【2】
【2】Central Nervous System Roles
l Research shows oxytocin modulates circuits in the amygdala, striatum, and prefrontal cortex, affecting trust, stress regulation, and social behavior.
【3】
l Ongoing studies investigate its relevance in autism, PTSD, schizophrenia, and affective disorders.
【4】
l Experimental findings suggest analgesic properties via OTR and opioid receptor interactions.
【5】
【3】Metabolic & Energy Research
l Suppression of appetite and enhanced energy expenditure observed in preclinical and human studies.
【6】
l Associated with improved glycemic regulation and thermogenesis.
【4】Immune & Anti-Inflammatory Effects
l Studies show oxytocin reduces pro-inflammatory cytokines such as TNF-α and protects tissues in inflammatory and ischemic models.
【7】
✅ Why Consider Oxytocin Acetate？
🧘 Social & emotional regulation: Associated with bonding, trust, and reduced stress in models.
🩹 Pain research: Demonstrates analgesic and antinociceptive effects in experimental systems.
🍽 Metabolic studies: Appetite suppression and energy balance modulation.
🔥 Energy & glucose regulation: Enhances thermogenesis and insulin sensitivity in preclinical models.
🛡 Immune modulation: Regulates cytokines and supports tissue resilience.
4. Future Oxytocin Acetate Research
l Enhanced Brain Delivery: Development of small-molecule OTR agonists (e.g., LIT-001) with improved bioavailability.
【8】
l Long-Acting Analogs: Lipidated versions such as Lipo-oxytocin-1 demonstrate prolonged behavioral and metabolic effects in rodents.
l Novel Formulations: Oral and mucosal approaches (e.g., “Oxipops”) are under investigation for systemic delivery.
【9】
l Metabolic Research: Ongoing trials explore oxytocin analogs in obesity and glucose regulation.
【10】
l Neuropsychiatric Applications: PTSD, autism, anxiety, and addiction are current research areas.
l Immunology & Organ Protection: Animal studies support oxytocin’s role in sepsis and ischemia-reperfusion models.
5. Application Areas
l Neuroendocrine & Behavioral Studies: Social interaction, trust, stress response.
l Pain & Analgesia Research: Alternative neuropeptide pathways to opioid models.
l Metabolic Studies: Appetite and weight regulation models.
l Immunology: Cytokine suppression and systemic inflammation research.
l Cardiovascular & Thermoregulation: Preclinical evidence for vascular and temperature homeostasis.
✅ Summary
Oxytocin Acetate is a multifunctional research peptide bridging classical reproductive biology with modern fields such as social neuroscience, metabolism, pain regulation, and immunology. Its evolving role in experimental pharmacology and biotechnology highlights its broad potential as a target for novel therapeutic strategies—though all applications remain within research contexts.
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
