1. What is Kisspeptin-10?
Kisspeptin-10 is the shortest and most bioactive fragment of the kisspeptin peptide family, consisting of 10 amino acids derived from the C-terminal region of Kisspeptin-54. It binds with high affinity to the GPR54 (KISS1R) receptor and has been widely studied for its role in modulating gonadotropin-releasing hormone (GnRH) signaling within research settings.
Kisspeptin-10 is primarily explored in scientific studies on neuroendocrine regulation, puberty onset, and hypothalamic-pituitary-gonadal (HPG) axis dynamics.
2. Kisspeptin-10 Structure
Sequence:YNWNSFGLRF
Molecular Formula: C₆₃H₈₃N₁₇O₁₄
Molecular Weight: 1302.4 g/mol
PubChem CID: 25240297
Synonyms: KISS-1, Protein KISS-1, metastin, Kp-10 peptide
3. Kisspeptin-10 Research
Kisspeptin-10 is a synthetic peptide fragment derived from the larger kisspeptin family, encoded by the KISS1 gene. In research models, it has been shown to interact with the GPR54 receptor (KISS1R), influencing GnRH secretion and downstream signaling pathways.
As the most potent fragment of the kisspeptin family, Kisspeptin-10 has become a focus of studies examining reproductive hormone regulation, neuroendocrine communication, and peptide-receptor binding specificity.
【1】Mechanism of Action
l Binds to GPR54 receptors on GnRH neurons, stimulating GnRH release in experimental settings.
l Modulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in research models.
l Provides insight into ovarian and testicular hormone regulation within endocrine studies.
l Investigated as an upstream regulator for understanding hormone feedback loops.
【2】Key Research Highlights
l Shown to elevate GnRH and gonadotropin activity in laboratory studies.
l Used in experimental models exploring puberty onset and endocrine development.
l Demonstrated activity in research exploring hormone balance and reproductive axis dynamics.
【3】Expert Insight
l Scientific reviews identify Kisspeptin-10 as a highly specific modulator of GnRH pathways.
l Researchers highlight its utility as a research tool for studying hypothalamic signaling and endocrine axis regulation.
✅ Why Consider Kisspeptin-10 (Research Use)?
🧬 Studied as a natural stimulator of GnRH, LH, and FSH pathways
⚙️ Useful in mapping endocrine and reproductive axis signaling
🌿 Provides a physiological model for upstream hormone regulation
🧠 Investigated in research on mood, metabolism, and neuroendocrine activity
4. Future Kisspeptin-10 Research
A. Endocrine Axis Studies
Explored as a tool in mapping hypothalamic-pituitary-gonadal (HPG) activity and its modulation in different experimental conditions.
B. Reproductive Biology Models
Ongoing studies examine its role in understanding ovarian follicle development, spermatogenesis models, and GnRH pulse generation.
C. Assisted Reproductive Technology Research
Being investigated as a controlled research model for ovulatory signaling and gonadotropin regulation.
D. Neuroendocrine & Metabolic Pathways
Research suggests Kisspeptin may interact with neural circuits involved in mood regulation, appetite, and metabolism.
E. Combination Research
Potential for combined use with other peptides in laboratory settings, such as:
GnRH analogs for reproductive signaling models
Follistatin for HPG axis studies
Metabolic peptides for energy regulation experiments
5. Application Area
l Endocrine Research Models – Mapping GnRH and gonadotropin signaling
l Neuroendocrine Studies – Understanding hypothalamic regulation of mood and metabolism
l Reproductive Axis Research – Exploring hormone regulation mechanisms in lab models
l Peptide-Receptor Interaction – Investigating KISS1R receptor specificity and activity
✅ Summary
Kisspeptin-10 is a neuroendocrine research peptide widely studied for its ability to:
✔️ Stimulate GnRH, LH, and FSH pathways in research models
✔️ Provide upstream regulation insight into endocrine feedback loops
✔️ Support experimental studies in puberty, hormone signaling, and metabolism
✔️ Serve as a selective research tool for endocrine and neuroendocrine applications
⚠️ Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro research use only. In-vitro studies (Latin: “in glass”) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
