1. What is Ipamorelin?
Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist designed to stimulate the natural release of growth hormone (GH) from the anterior pituitary. It belongs to the GHRP family but is distinguished by its high receptor specificity, minimal side effects, and lack of significant impact on cortisol or prolactin.
Ipamorelin has been widely studied in research for its potential roles in GH axis regulation, muscle preservation, fat metabolism, sleep improvement, and recovery support.
2. Ipamorelin Structure
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular formula:C₃₈H₄₉N₉O₅
Molar Mass: 711.85296
CAS number:170851-70-4
PubChem: CID 20754357
Synonyms: Ipamorelin Acetate, IPAM, NNC-26-0161
3. Ipamorelin Research
Mechanism of Action
l GHSR-1a Binding: Activates pituitary somatotrophs to release GH in a pulsatile manner 【1】.
l Minimal Off-Target Effects: Does not elevate prolactin or cortisol, avoiding water retention, adrenal stress, or mood disruption 【2】.
l IGF-1 Upregulation: Enhances hepatic IGF-1 production, supporting tissue repair and regeneration.
l Neuroendocrine Modulation: Influences appetite, circadian rhythm, and metabolic homeostasis.
Clinical & Biological Outcomes
l 💪 Muscle Support: Stimulates GH and IGF-1, aiding in muscle building and recovery.
l 🧠 Sleep Optimization: Improves slow-wave sleep and stress adaptation.
l 🩹 Tissue Repair: Promotes collagen synthesis, cartilage integrity, and wound healing.
l ⚖️ Metabolic Benefits: Enhances fat utilization and reduces visceral fat accumulation.
Expert Commentary
l Journal of Endocrinological Investigation (2020): “Ipamorelin’s selectivity makes it suitable for long-term GH modulation without collateral endocrine disruption.”
l Dr. Eric Braverman (Neuroendocrinologist): “Among GH secretagogues, Ipamorelin is one of the safest for clinical use, particularly in metabolic and anti-aging protocols.”
✅ Why Consider Ipamorelin?
✔️ Clean GH stimulation without cortisol/prolactin elevation
💉 Suitable for long-term protocols with minimal desensitization risk
🧬 Boosts IGF-1 and systemic tissue regeneration
🛏️ Improves sleep quality, stress recovery, and fat metabolism
🧠 Supports neuroendocrine balance and circadian alignment
🔁 Combines effectively with CJC-1295, BPC-157, Tesamorelin, or GHK-Cu
4. Future Ipamorelin Research
· A. Anti-Aging & Longevity Protocols
Explored in age-related sarcopenia, sleep disorders, and skin degeneration; long-term use may improve biomarkers of aging, VO₂ max, and heart rate variability.
· B. Post-Surgical & Injury Recovery
Studied for accelerating soft tissue repair, ligament recovery, and cartilage regeneration through IGF-1–mediated collagen synthesis.
· C. GH Axis Restoration (PCT)
Used in post-cycle therapy for anabolic steroid users to restore circadian GH rhythm and prevent muscle loss.
· D. Pediatric & Geriatric Endocrinology
Under evaluation for GH deficiency treatment in children and elderly populations with fewer risks compared to exogenous GH.
· E. Combination Peptide Therapies
Frequently paired with:
CJC-1295: Amplifies GH pulse duration
GHK-Cu: Enhances skin healing
BPC-157: Supports gut and tendon repair
IGF-1 LR3: Increases anabolic and regenerative synergy
5. Application Area
l 💪 Muscle Growth & Fat Loss
Preserves lean muscle and reduces visceral adiposity.
l 🧠 Sleep & Neuroendocrine Balance
Enhances slow-wave sleep and parasympathetic recovery 【3】.
l 🩹 Tissue & Joint Regeneration
Supports post-surgical recovery, ligament healing, and cartilage preservation.
l ⚙️ Longevity & Preventive Medicine
Provides mild, sustainable GH stimulation while improving insulin sensitivity and metabolic balance.
l 🧪 Post-Cycle Recovery
Restores natural GH axis and prevents atrophy following steroid or hormone suppression.
✅ Summary
Ipamorelin is a highly selective GH secretagogue that offers:
✔️ Safe, clean stimulation of GH without prolactin/cortisol elevation
✔️ Improvements in muscle retention, fat loss, sleep quality, and recovery
✔️ Suitability for long-term anti-aging and wellness protocols
✔️ Strong synergy with other regenerative peptides
✔️ A preferred option for hormonal restoration and PCT applications
Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: “in glass”) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
