1. 什么是IGF-1 DES？
IGF-1 DES（Des(1–3) Insulin-like Growth Factor-1）是天然IGF-1的截短同工型，其中从N端移除了前三个氨基酸。这种修饰显著增强了生物活性，通过减少与IGF结合蛋白（IGFBPs）的结合，从而在组织部位增加游离的生物活性IGF-1。
IGF-1 DES的特点是半衰期短和局部活性，使其在靶向肌肉肥大、肌腱修复、皮肤年轻化和特定部位再生协议的研究中特别有用。
2. IGF-1 DES 结构
序列：TLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKAAKSA
分子式: C₃₁₉H₅₀₁N₉₁O₉₆S₇
分子量：7371 g/mol
PubChem CID: 135331146
CAS 号:112603-35-7
Synonyms: Insulin-like growth factor 1, des-(1-3)-, Des(1-3) IGF-1, 4-70-insulin-like growth factor 1
3. IGF-1 DES Research
⚙️ Mechanism of Action
l Enhanced IGF-1R Binding: Strong stimulation of PI3K/Akt/mTOR and MAPK/ERK pathways, promoting proliferation, hypertrophy, and tissue repair 【1】.
l Reduced IGFBP Affinity: Lower sequestration by IGFBPs, resulting in higher localized activity 【2】.
l Localized Action: Very short half-life (~20–30 minutes) ensures effects are site-specific, unlike IGF-1 LR3 which acts systemically.
📊 Research Highlights
l In vitro and animal studies confirm myoblast differentiation, satellite cell activation, and angiogenesis at microinjury sites.
l Investigated for use in localized muscle hypertrophy, tendon/joint recovery, and dermal repair following trauma or procedures.
Expert Commentary
l Hormone Research in Paediatrics: “IGF-1 DES is particularly suitable for site-directed therapy where regional enhancement of IGF-1 signaling is required without systemic GH elevation.”
l Peptides in Regenerative Medicine (2023): “Its short half-life allows for precision regenerative therapy with minimized systemic exposure.”
✅ Why Consider IGF-1 DES?
l 🔬 10× potency at target tissue vs. native IGF-1
l 💪 Ideal for localized hypertrophy & injury site-specific healing
l 🧬 Avoids IGFBP sequestration, maximizing receptor binding
l 🛠️ Effective in regenerative research for muscle, tendon, and skin repair
l ⏳ Short duration = lower systemic exposure and minimized hormonal disruption
4. Future IGF-1 DES Research
· A. Orthopedic & Tendon Regeneration
Studies on Achilles tendinopathy, rotator cuff tears, and ligament injuries, aiming for accelerated collagen remodeling 【3】.
· B. Targeted Muscle Growth & Rehabilitation
Evaluated in post-injury recovery and resistance training models to restore lost muscle volume.
· C. Anti-Aging Dermatology
Combined with microneedling or laser therapy for wrinkle reduction, scar remodeling, and stretch mark repair.
· D. Neuroregeneration
Explored for localized recovery in peripheral nerve injury and spinal disc degeneration, with evidence of IGF-1–mediated neurogenesis 【4】.
· E. Delivery Innovations
Development of topical hydrogel, microemulsion, and scaffold-based delivery systems, often paired with BPC-157, TB-500, or GHK-Cu.
5. Application Area
l 🧪 Tissue Repair & Regeneration
Muscle microtears, tendon strengthening, ligament healing.
l 💪 Localized Muscle Growth
Site-specific hypertrophy, post-surgical muscle atrophy prevention.
l 🧖 Dermatology & Skin Healing
Collagen regeneration, scar reduction, dermal rejuvenation.
l 🧠 Nerve & Spine Recovery
Peripheral nerve trauma, spinal disc support, neuron-glia repair.
l 🛡️ Surgical & Post-Procedural Recovery
Applied in research with PRP, stem cells, or microneedling to enhance ECM rebuilding and angiogenesis.
✅ Summary
IGF-1 DES is a localized, short-acting IGF-1 analog with distinct regenerative potential:
✔️ 10× potency at tissue sites
✔️ Minimal IGFBP interference for higher free activity
✔️ Ideal for site-directed muscle, tendon, and skin repair
✔️ Low systemic exposure due to short half-life
✔️ Compatible with regenerative peptide and cell-based protocols
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