1. What is Hexarelin Acetate?
Hexarelin Acetate is a synthetic hexapeptide classified as a growth hormone-releasing peptide (GHRP). It binds to the ghrelin receptor (GHSR-1a), stimulating growth hormone (GH) secretion in a pulsatile manner. Compared to other GHRPs such as GHRP-2 and GHRP-6, Hexarelin is noted for its stronger potency and longer half-life, making it a valuable research tool in the study of GH regulation, metabolic function, and cardiovascular protection.
2. Hexarelin Acetate Structure
Sequence: His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys
Molecular Formula: C₄₇H₅₈N₁₂O₆
Molecular Weight: 887.059 g/mol
PubChem CID:6918297
CAS Number: 140703-51-1
3. Hexarelin Acetate Research
⚙️ Mechanism of Action
l Pituitary Activation: Hexarelin binds to the GHSR-1a receptor, promoting GH release from pituitary somatotrophs 【1】.
l Ghrelin Mimicry: Acts as a ghrelin receptor agonist, influencing appetite, gastric motility, and energy conservation.
l GH–IGF-1 Upregulation: Pulsatile GH stimulation increases IGF-1 production, relevant to studies of cellular regeneration and metabolic balance.
l Cardiac Pathways: Hexarelin also binds to cardiac-expressed ghrelin receptors, supporting research into cardioprotection, vascular tone, and anti-fibrotic mechanisms 【2】.
Research Highlights
l Documented increases in GH and IGF-1 within 15–60 minutes of administration.
l Preclinical and translational studies suggest myocardial protection, improved ventricular function, and reduced apoptosis in ischemic models.
l Investigated for muscle mass preservation, stress recovery, and neuroendocrine regulation.
Expert Insights
l Frontiers in Endocrinology (2022): “Hexarelin exhibits the strongest GH-releasing activity among GHRP analogs, with additional cardiovascular benefits.”
l Hormone researchers note its favorable half-life, stability, and receptor selectivity, distinguishing it from shorter-acting GHRPs.
✅ Why Consider Hexarelin Acetate?
l 💉 More potent than GHRP-2/6 in GH release research
l ❤️ Investigated for cardioprotective properties in ischemic models
l 💪 Supports studies on muscle preservation, repair, and metabolic recovery
l 🔁 Longer half-life → fewer administrations and stable GH pulsatility
l 🧠 Explored for neuroendocrine resilience and sleep depth modulation
l 🧪 Synergistic with CJC-1295, IGF-1 LR3, or MK-677 in advanced peptide protocols
4. Future Hexarelin Acetate Research
A. Cardiovascular Applications
Explored in heart failure, post-infarction remodeling, and ischemia-reperfusion injury models 【3】.
B. Metabolic & Lipid Regulation
Studies indicate effects on fat oxidation, insulin sensitivity, and glucose metabolism 【4】.
C. Neuroendocrine & Brain Aging
Potential applications in neurodegeneration research (e.g., Parkinson’s, Alzheimer’s), focusing on GH/IGF-1–linked neurogenesis and oxidative stress.
D. Endocrine Axis Rebooting
Investigated as part of hormone recovery protocols, particularly in post-suppression or aging models.
E. Delivery & Formulation Innovations
Development of PEGylated forms, microspheres, and oral prodrugs to improve stability, bioavailability, and convenience.
5. Application Area
💪 Muscle & Endocrine Research
Sarcopenia, cachexia, and anabolic recovery models
❤️ Cardiovascular Studies
Myocardial ischemia, hypertensive remodeling, chronic heart failure
🔬 Hormonal Recalibration
HPG and GH axis recovery in experimental protocols
🧠 Neurocognitive Exploration
Effects on sleep depth, stress recovery, and neuronal plasticity
⚖️ Metabolic Health
Fat metabolism, insulin sensitivity, and energy balance
✅ Summary
Hexarelin Acetate is a potent GH secretagogue with:
✔️ Stronger and more sustained GH/IGF-1 release than GHRP-2/6
✔️ Documented cardioprotective and metabolic research potential
✔️ Extended half-life and improved receptor binding stability
✔️ Broad research applications in muscle, heart, neuroendocrine, and aging models
Disclaimer:
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: “in glass”) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
