1. What is Epitalon?
Epitalon (also called Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally developed from research on pineal gland extracts. It has been investigated for its potential to influence telomerase activity, circadian rhythm regulation, and cellular processes related to aging. Epitalon has become a subject of interest in longevity research and peptide bioregulation.
2. Epitalon Structure
Sequence: Ala-Glu-Asp-Gy
Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.349 g/mol
PubChem CID:219042
CAS Number: 307297-39-8
3. Epitalon Research
Mechanism of Interest
l Telomerase Modulation: Reported to stimulate telomerase activity in experimental systems, potentially supporting telomere maintenance 【1】.
l Antioxidant Regulation: Shown to influence antioxidant enzymes such as superoxide dismutase (SOD), reducing lipid peroxidation in cell studies 【2】.
l Pineal–Pituitary Axis: Research suggests possible normalization of melatonin secretion and circadian patterns.
Experimental Findings
l Longevity Research: In rodent studies, long-term Epitalon administration has been associated with lifespan extension 【3】.
l Oncostatic Effects: Observed reduction in spontaneous tumor development in aged animal models.
l Endocrine Modulation: Some studies suggest normalization of reproductive hormone levels in experimental systems.
Human Research (Preliminary)
l Small-scale studies in elderly subjects reported improvement in melatonin rhythm and sleep quality.
l Investigated for protective effects in vision-related aging, though evidence remains limited and exploratory.
✅ Why Consider Epitalon (Research Context)?
l 🔬 Studied for telomerase activation and genome stability support
l 🌙 Research interest in pineal and circadian rhythm regulation
l 🧬 Reported to influence oxidative stress and cellular defense pathways
l 👁 Investigated in models of vision and retinal protection
l ⏳ Considered a peptide of scientific interest in aging and bioregulatory research
4. Future Epitalon Research
A. Epigenetic & Genomic Studies
l Ongoing efforts to map chromatin modifications (histone acetylation, methylation) after Epitalon exposure.
l Studies into DNA methylation and biological age “epigenetic clocks.”
B. Cellular Senescence & Autophagy
l Research into Epitalon’s role in reducing senescence markers (β-galactosidase) and supporting autophagic flux.
l Investigations into neural stem cell rejuvenation and SASP modulation.
C. Organ & System Studies
l Cardiovascular: Endothelial health and nitric oxide regulation.
l Neuroendocrine Axis: Preserving pituitary–hypothalamic signaling.
l Skin Aging Models: Collagen synthesis and fibroblast viability.
D. Delivery Systems
l Research on oral nanocarriers, nasal sprays, and peptide stabilization for improved pharmacokinetics.
E. Synergistic Research
l Combined use with other investigational peptides (e.g., GHK-Cu, thymic peptides, NAD⁺ boosters).
5. Application Area (Research Use Only)
Epitalon is primarily studied in:
l 🧪 Aging and telomere biology research
l 🌙 Circadian rhythm and pineal gland studies
l 🧬 Cellular senescence and oxidative stress models
l 👁 Retinal and vision-related research contexts
l 🧠 Neuroendocrine and sleep regulation studies
⚠ Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
