1. What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (9 amino acids) that was originally isolated from the hypothalamus. It has been investigated in neuroscience and sleep physiology research for its association with delta-wave activity during deep sleep. Studies suggest DSIP may play a role in regulating sleep cycles, stress responses, and neuroendocrine balance, although its exact endogenous function is still under active investigation 【1】
2. DSIP Structure
Sequence: Trp-Ala-G|y-G|y-Asp-Ala-Ser-Gly-Glu
Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight:848.824 g/mol
PubChem CID: 68816
CAS Number: 62568-57-4
Synonyms: Emideltide,DSIP nonapeptide, Deltaran
3. DSIP Research
Research Overview
DSIP is studied as a neuromodulator peptide with reported effects on delta-wave sleep, stress hormone regulation, and circadian rhythms. Unlike sedative compounds, DSIP has been described in experimental studies as influencing neurotransmitter and endocrine systems rather than acting through direct sedation.
【1】 Mechanism of Action (Research Context)
l 🧠 GABAergic modulation: Experimental findings suggest DSIP may interact with GABA-A pathways, supporting inhibitory neurotransmission 【2】.
l 🔄 HPA axis interaction: DSIP has been studied for its influence on ACTH and cortisol dynamics in stress models 【3】.
l ⏱ Circadian alignment: Research indicates possible modulation of melatonin secretion and nocturnal growth hormone release.
l 🧪 Opioid/NMDA interaction: Certain studies suggest DSIP may modulate nociceptive thresholds, relevant to pain-related sleep disturbances.
【2】 Research Applications
DSIP has been investigated in the following research areas:
l Sleep physiology: Experimental studies report associations with increased delta-wave activity and sleep continuity 【4】.
l Stress modulation: Preclinical and small-scale studies describe effects on cortisol and ACTH regulation 【5】.
l Neurocognitive studies: Investigated for roles in neuroinflammation, mood balance, and fatigue resistance.
l Chronobiology research: Explored in circadian rhythm alignment, jet lag models, and shift-work simulation studies 【6】.
✅ Why Consider DSIP (Research Context)?
l 🌙 Studied for its role in delta-wave sleep research
l 🔄 Associated with hormonal and stress modulation in experimental settings
l 🧠 Explored for neurocognitive and mood regulation effects
l 🧬 Investigated as non-habit-forming in preclinical studies
l ⚖️ Relevant in chronobiology and circadian rhythm research
4. Future DSIP Research
【1】 Endogenous Production & Mechanism
Research gaps remain regarding DSIP’s origin and receptor interactions. Future studies aim to clarify whether DSIP is encoded or derived from larger precursors, and to identify its specific receptor targets 【7】.
【2】 Functional Applications
Emerging preclinical studies suggest roles in:
l Stroke recovery and mitochondrial resilience 【8】
l Pain modulation and neuroprotection 【9】
l Development of analogs with enhanced stability and bioavailability
5. Application Area
DSIP is primarily studied in the following domains:
l 🧪 Neuroscience & sleep research, focusing on non-sedative sleep modulation
l ⏳ Endocrine studies, including cortisol and growth hormone regulation
l 🧠 Mood and stress adaptation research
l 🧬 Chronobiology, examining circadian rhythm and melatonin regulation
⚠ Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
