1. What is CJC-1295 with DAC?

CJC-1295 with Drug Affinity Complex (DAC) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), designed to extend the half-life of native GHRH. By attaching a DAC moiety, CJC-1295 achieves prolonged stability in circulation, allowing sustained stimulation of growth hormone (GH) release in experimental systems. It is primarily studied for its role in endocrine signaling, growth hormone dynamics, metabolic regulation, and cellular repair pathways.

2. CJC-1295 with DAC Structure

Sequence: Modified GHRH (1-29) with DAC binding

Molecular Formula: C₁₆₅H₂₇₁N₄₇O₄₆

Molecular Weight: 3647.09 g/mol

CAS Number: 863288-34-0

PubChem CID: 56841945

Synonyms: DAC:GRF (Drug Affinity Complexed Growth Releasing Factor), Modified GRF 1-29 with DAC

3. CJC-1295 with DAC Research

【1】 Pharmacokinetic Advantage

•  Extended half-life: DAC binding extends peptide activity from minutes (native GHRH) to ~5–8 days in preclinical models【1】.
•  Stable GH release: Promotes pulsatile GH secretion while avoiding constant overstimulation.

【2】 Growth Hormone & IGF-1 Research

•  IGF-1 modulation: Repeated studies show sustained increases in insulin-like growth factor-1 (IGF-1) levels in experimental settings【2】.
•  Endocrine system modeling: Used to simulate pituitary responsiveness and natural circadian GH pulses.

【3】 Tissue & Cellular Outcomes

•  Metabolic studies: Observed improvements in glucose handling, lipid metabolism, and mitochondrial support in rodent models.
•  Repair & recovery models: Early research shows potential in wound healing and connective tissue studies.
•  Neuroendocrine effects: Suggested involvement in hypothalamic signaling and stress regulation.

✅ Why Consider CJC-1295 with DAC?

⏳ Prolonged activity: DAC modification ensures days-long duration in systemic circulation.

🔬 Endocrine modeling: Ideal for studying GH/IGF-1 axis without continuous infusion.

🧬 Metabolic insights: Provides research data on glucose, lipid, and mitochondrial pathways.

🛠 Versatile peptide tool: Applicable in tissue repair, regenerative, and aging studies.

🌍 Research-backed: Evaluated in both animal models and early clinical research.

4. Future CJC-1295 with DAC Research

Comparative studies: Benchmarking CJC-1295 DAC vs. non-DAC analogs (e.g., Modified GRF 1-29).

Metabolic disorder exploration: Investigating roles in obesity, insulin resistance, and metabolic syndrome.

Tissue-specific effects: Assessing GH-mediated signaling in muscle, bone, skin, and connective tissues.

Neuroendocrine axis studies: Evaluating hypothalamic–pituitary–adrenal cross-talk.

Delivery optimization: Exploring controlled-release and nanoformulation systems for research stability.

5. Application Areas

✅ Summary

CJC-1295 with DAC is a long-acting GHRH analog engineered for stability and extended biological half-life. It has shown consistent research results in GH/IGF-1 axis stimulation, metabolic regulation, and tissue recovery studies. Its DAC modification makes it a powerful tool for exploring endocrine rhythms, regenerative biology, and systemic homeostasis in modern peptide research.

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The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.