1. What is AOD-9604?
AOD-9604 is a synthetic peptide fragment derived from the C-terminal end of human growth hormone (HGH), corresponding to amino acids 176–191. It has been investigated in research settings for its role in stimulating fat metabolism and promoting lipolysis while not influencing blood sugar or IGF-1 levels. AOD9604 continues to be of interest in studies focusing on metabolic modulation and body composition research.
2. AOD9604 Structure
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Disulfide bridge Cys7-Cys15
Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight: 1815.12 g/mol
PubChem CID: 16131447
CAS Number:221213-10-3
3、AOD-9604 research
AOD9604: Metabolic Modulator & Fat-Targeting Research Peptide
AOD9604 is a 16-amino-acid peptide fragment investigated for its role in lipid metabolism. It has been studied in both animal and early human research for its ability to influence fat oxidation and storage pathways 【1】.
【1】 Experimental Research on Obesity Models
In animal studies and exploratory human trials, AOD9604 has been evaluated for effects on body weight regulation and fat composition. Some studies reported modest differences in fat mass reduction compared to placebo, though findings have been mixed and not conclusive 【2】, 【3】.
【2】 Clinical Evidence (Exploratory)
Early-phase trials evaluated AOD9604 in subjects with obesity. While some results suggested modest changes in weight reduction, larger Phase 2B studies did not confirm significant efficacy, indicating the need for further dose optimization and mechanistic studies.
【3】 Safety Profile in Research
Studies to date have suggested that AOD9604 is generally well tolerated in research contexts, showing no major impact on insulin sensitivity or IGF-1 levels. No anti-AOD9604 antibodies were detected, and no severe adverse outcomes were reported 【4】.
【4】 Mechanism of Action (Exploratory)
Lipolysis Activation: Promotes breakdown of fat stores, possibly through β₃-adrenergic pathways.
Anti-Lipogenesis: May inhibit new fat formation, contributing to research interest in body composition regulation 【5】.
4. Future AOD-9604 Research
Future investigations may expand on AOD9604’s role as a metabolic modulator, with research directions including:
l Metabolic health: Evaluation in models of insulin sensitivity, glucose uptake, and lipid signaling 【6】.
l Fat metabolism: Further mechanistic studies into β₃-adrenergic receptors, hormone-sensitive lipase (HSL), and acetyl-CoA carboxylase (ACC).
l Tissue and regenerative studies: Preclinical work has suggested potential for cartilage metabolism and joint biology 【7】, though these findings are preliminary and require significant validation.
Overall, AOD9604 remains an experimental peptide of research interest, with no approved therapeutic applications.
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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
