1. What is Adipotide?
Adipotide (also known as FTPP) is a synthetic peptide investigated for its ability to selectively affect blood vessels that supply white adipose tissue. Through its mechanism of targeting prohibitin receptors on fat-associated vasculature, Adipotide has been studied in preclinical research for its potential to influence fat tissue biology and related metabolic pathways.
2.Adipotide Structure
Sequence:Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-(Lys-Leu-Ala-Lys-Leu-Ala-Lys）₂ Molecular Formula:C₁₁₁H₂₀₆N₃₆O₂₈S₂
Molecular Weight: 2557.2 g/mol
3.Adipotide Research
Adipotide: Vascular-Targeted Research Peptide
Adipotide is classified as a pro-apoptotic peptide that interacts with prohibitin receptors on blood vessels in adipose tissue. By disrupting vascular supply to fat cells, it has been explored for its impact on adipose reduction, metabolic biomarkers, and vascular targeting strategies.
【1】 Research on Fat Tissue & Metabolic Indicators
In non-human primate models, Adipotide exposure has been associated with reductions in visceral fat volume and measurable changes in insulin-related biomarkers 【1】. These exploratory findings suggest a role for vascular-targeted peptides in fat tissue studies.
【2】 Mechanism of Action: D(KLAKLAK)₂ Sequence
The peptide sequence D(KLAKLAK)₂ disrupts mitochondrial function in endothelial cells of fat vasculature, initiating programmed cell death (apoptosis). This selective mechanism differentiates Adipotide from systemic weight-regulation approaches 【2】.
【3】 Preclinical Insights
l Treated animal models showed reduced food consumption and changes in energy metabolism.
l BMI and visceral fat measurements decreased in some studies, while lean tissue was relatively unaffected.
l Improvements in insulin sensitivity were observed in certain preclinical experiments, suggesting relevance to metabolic research.
【4】 Ongoing Research
Adipotide has been listed in exploratory clinical trial registries to study its safety and research outcomes 【3】. While early-stage findings in animal studies are of scientific interest, Adipotide is not approved for therapeutic use and remains under investigation.
✅ Why Consider Adipotide (Research Perspective)
l Targeted interaction with adipose vasculature
l Demonstrated fat tissue modulation in preclinical models
l Documented interest in insulin sensitivity and metabolic markers
l Novel vascular-targeting mechanism for scientific exploration
4. Future Adipotide Research
Future research directions may include:
l Obesity & metabolic studies: Further evaluation in preclinical models of fat reduction and metabolic regulation.
l Diabetes-related research: Potential exploration of insulin sensitivity pathways.
l Cancer-related vascular studies: As an anti-angiogenic molecule, Adipotide may also be studied for its possible role in tumor vasculature models.
Advancements in peptide engineering may improve the selectivity, safety, and bioavailability of Adipotide analogs. However, all investigations remain experimental and limited to laboratory research.
5. Application Area
Adipotide is actively studied in the following research contexts:
🧪 Experimental adipose biology and obesity models
🔬 Metabolic syndrome & insulin resistance studies
🧬 Vascular-targeted peptide design
🩺 Exploratory pharmacology in anti-angiogenesis research
Its relevance lies in mechanistic research, rather than behavioral or CNS-mediated weight regulation.
⚠ Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
