1. What is ACE-031?
ACE-031 is a recombinant peptide designed to inhibit myostatin, a regulatory protein that limits muscle growth. It acts by binding to myostatin and preventing its interaction with the activin receptor type II. ACE-031 has been primarily investigated in preclinical and experimental studies focused on muscle physiology, bone health, and metabolic balance.
2. ACE-031 Structure
Sequence: H-Ile-Glu-Gly-Asp-Ala-Pro-Lys-Pro-Ala-His-Pro-Ile-OH
Molecular Formula: C₁₃₃H₂₂₇N₄₃O₃₃
Molecular Weight: 2,956.5 g/mol
3. ACE-031 Research
ACE-031: Myostatin Pathway Inhibitor Peptide
ACE-031 is a soluble Activin receptor IIB (ActRIIB)-Fc fusion protein that acts as a decoy receptor. By neutralizing myostatin and related ligands of the Transforming Growth Factor-β (TGF-β) superfamily, ACE-031 has been explored for its influence on muscle composition, fat metabolism, and bone physiology in research models.
【1】 Research on Muscle Physiology & Lean Mass
Experimental studies have examined ACE-031 for its role in altering lean body composition. Early-stage investigations suggested measurable shifts in muscle and bone metabolism biomarkers, though these remain exploratory and not clinically validated【1】.
【2】 Mechanism: Decoy Receptor for Myostatin
By blocking myostatin and activin A, ACE-031 reduces inhibitory signals on muscle tissue. This mechanism has been a focus of research into bone formation and fat metabolism regulation.
【3】 Animal Model Data
In animal studies, ACE-031 exposure was associated with enhanced oxidative metabolism, changes in exercise-related parameters, and increased bone mineral density via reduced osteoclast activityIt also promoted fat oxidation, reduced adipose tissue, and stimulated bone mineral density (BMD) by suppressing osteoclast activity 【2】
【4】 Exploratory Applications in Research
ACE-031 has been investigated in contexts such as muscle-wasting disorders and cachexia models. While these findings highlight scientific interest, ACE-031 remains limited to experimental and preclinical research, with no approved therapeutic use.
4. Future ACE-031 Research
Future investigations are expected to further explore ACE-031’s role in:
l Neuromuscular research (e.g., sarcopenia, Duchenne muscular dystrophy, cachexia models)
l Metabolic studies, including fat metabolism, insulin sensitivity, and glucose uptake
l Peptide engineering approaches aimed at improving stability, selectivity, and bioavailability
Current interest also includes evaluating ACE-031 in combination with exercise protocols or metabolic regulators, though these remain speculative research pathways.
ACE-031 continues to be studied in in-vitro and preclinical models as part of broader research into myostatin inhibition. Official therapeutic applications are not approved, and all available data remain in the domain of experimental science.
Related Sources:
l NIH Clinical Trials Database – Archived ACE-031 Study 【3】
l PubMed – Myostatin Pathway Inhibition 【4】
5. Expert Insights on ACE-031
“ACE-031 use demonstrated trends for pharmacodynamic effects on lean mass, fat mass, and bone-related biomarkers.”
Muscle & Nerve (2017) 【5】
“ACE-031 functions as a decoy receptor, binding to myostatin and other negative regulators of muscle mass.”
IronMagazine – Research Review
These observations highlight ACE-031’s mechanistic value in research rather thantherapeutic outcomes. Its scientific importance lies in:
l Providing a model system for myostatin inhibition
l Expanding research into muscle, fat, and bone interactions
l Contributing to the understanding of TGF-β superfamily signaling
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
