1. What is 5-AMINO-1MQ?

5-AMINO-1MQ is a small-molecule peptide-related research compound studied for its effects on cellular metabolism, adipogenesis, and energy regulation. It functions primarily as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to methylation balance, NAD⁺ metabolism, and fat cell activity. By blocking NNMT, 5-AMINO-1MQ has been shown in laboratory settings to influence pathways related to weight regulation, metabolic activity, and mitochondrial function.

2. 5-AMINO-1MQ Structure

Molecular Formula: C₁₀H₁₁N₂

Molecular Weight: 159.21 g/mol

CAS Number: 42464-96-0

Synonyms: 1-Methylquinolinium-5-amine, 1MQ

3. 5-AMINO-1MQ Research

【1】 Molecular & Mechanistic Highlights

•  NNMT inhibition: Acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), which regulates nicotinamide and methyl donor balance【1】.
•  NAD⁺ metabolism link: Influences cellular NAD⁺ salvage pathways, important for mitochondrial energy and metabolic signaling.
•  Methylation balance: Reduces consumption of SAM (S-adenosylmethionine), preserving methylation potential for DNA, proteins, and lipids【2】.

【2】 Preclinical Findings

•  Adipocyte metabolism: In vitro studies show reduced fat cell size and number following NNMT inhibition.
•  Energy expenditure: Mouse models demonstrated increased oxygen consumption and metabolic activity in adipose tissues.
•  Metabolic health signals: Associated with improved insulin sensitivity, reduced adipose hypertrophy, and altered lipid metabolism in research models【3】.

【3】 Synergy & Adjacent Research

•  NAD⁺ boosters: NNMT inhibition may enhance the availability of nicotinamide for NAD⁺ salvage, complementing compounds like NMN or NR.
•  Mitochondrial resilience: Early research links NNMT inhibition with better mitochondrial performance under metabolic stress.

✅ Why Consider 5-AMINO-1MQ ?

🔬 Targeted NNMT inhibition: Direct action on a key metabolic enzyme.

⚡ Energy metabolism: Linked to higher mitochondrial activity and oxygen consumption.

🧬 NAD⁺ pathway support: May complement NAD⁺ precursors in research contexts.

📉 Adipocyte regulation: Associated with smaller, less hypertrophic fat cells in preclinical studies.

🛡 Epigenetic & methylation balance: Preserves SAM-dependent pathways by reducing NNMT demand.

🌍 Broad metabolic relevance: Useful in research of obesity, diabetes, and cellular bioenergetics.

4. Future 5-AMINO-1MQ Research Directions

Expanded metabolic trials: Broader studies on NNMT inhibition in obesity, diabetes, and metabolic syndrome models.

NAD⁺ & mitochondrial profiling: Examine interaction with NAD⁺ salvage and mitochondrial function under stress.

Epigenetic mapping: Detailed studies on DNA/histone methylation balance and gene regulation.

Combination strategies: Evaluate synergy with NAD⁺ precursors, sirtuin activators, and peptide bioregulators.

Organ-specific exploration: Research in liver, muscle, and brain tissues to assess systemic vs localized NNMT inhibition.

5. Application Areas (Research Use)

✅ Summary

5-AMINO-1MQ is a potent NNMT inhibitor studied for its effects on adipocyte metabolism, mitochondrial function, and NAD⁺ pathways. By modulating methylation balance and energy expenditure, it provides a valuable tool for research into obesity, diabetes, metabolic health, and cellular energetics. Its broad preclinical evidence base and synergy with NAD⁺ boosters make it an exciting subject for ongoing exploration in metabolism-focused studies.

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The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.